Early osteoarthritis after anterior cruciate ligament reconstruction: early identification and management
Anterior cruciate ligament (ACL) injury is a well-established risk factor for the accelerated development of knee osteoarthritis (OA), irrespective of management approach – conservative exercise therapy or surgical ACL reconstruction (ACLR).
The development and progression of knee OA after ACLR is typically evaluated using radiographs over the medium to long-term (i.e., >5-10 years post-surgery). Given the need to focus on prevention strategies, the use of more sensitive imaging modalities, such as magnetic resonance imaging (MRI), to detect degenerative changes in the earliest stages of disease, is expanding. Yet, little consideration has been given to the progression of early stages of disease, and the risk factors for these changes, which may provide new avenues to pursue strategies to reduce the risk of early-onset knee OA development and progression. Therefore, the aims of this Arthritis Australia and La Trobe University funded research project are to evaluate the rates and patterns of progression of early knee OA features 1 to 5 years after ACLR, and to identify modifiable risk factors for these early structural changes.
Staff involved: Brooke Patterson, Adam Culvenor, Kay Crossley, Joshua Stefanik, Ali Guermazi
Publications:
Patterson BE, Crossley KM, Perraton L, Kumar AS, King M, Heerey J, Barton CJ, Culvenor AG. (2019) Limb symmetry index on a functional test battery improves between one and five years after anterior cruciate ligament reconstruction, primarily due to worsening contralateral limb function. Physical Therapy in Sport (in press).
Patterson BE, Culvenor AG, Barton CJ, Guermazi A, Stefanik JJ, Morris HG, Whitehead TS, Crossley KM. (2020) Poor functional performance 1-year after ACL reconstruction increases the risk of early osteoarthritis progression. British Journal of Sports Medicine (epub ahead of print).
Hart HF, Culvenor AG, Guermazi A, Crossley, KM. (2020) Worse knee confidence, fear of movement, psychological readiness to return-to-sport and pain are associated with worse function after ACL reconstruction. Physical Therapy in Sport. 41; 1-8.
Patterson BE, Culvenor AG, Barton CJ, Guermazi A, Stefanik JJ, Crossley KM. (2020) Patient-reported outcomes one to five years after anterior cruciate ligament reconstruction: the effect of combined injury and associations with osteoarthritis features defined on magnetic resonance imaging. Arthritis Care Research. 72;412-22.
Macri E, Patterson B, Crossley KM, Stefanik JJ, Guermazi A, Blomqvist E, Khan K, Whitehead T, Morris H, Culvenor AG. (2019) Does patellar alignment or morphology predict worsening of patellofemoral disease within the first 5 years after ACL reconstruction. European Journal of Radiology. 113:32-8.
Patterson BE, Culvenor AG, Barton CJ, Guermazi A, Stefanik JJ, Morris HG, Whitehead TS, Crossley KM. (2018) Worsening knee osteoarthritis features on magnetic resonance imaging one to five years following anterior cruciate ligament reconstruction. American Journal of Sports Medicine. 46;2873-83.
Macri EM, Culvenor AG, Morris HG, Whitehead TS, Russell TG, Khan KM, Crossley KM. (2018) Lateral displacement, sulcus angle and trochlear angle are associated with early patellofemoral osteoarthritis following anterior cruciate ligament reconstruction. Knee Surgery, Sports Traumatology & Arthroscopy. 26;2622-9.
Culvenor AG, Patterson BE, Guermazi A, Morris HG, Whitehead TS, Crossley KM. (2018) Accelerated return to sport after anterior cruciate ligament reconstruction and early knee osteoarthritis features at 1 year: an exploratory study. PM&R 10;349-56.
Hatton AL, Crossley KM, Clark RA, Whitehead TS, Morris HG, Culvenor AG. (2017) Between-leg differences in challenging single-limb balance performance one year following anterior cruciate ligament reconstruction. Gait & Posture. 52;22-5.
Culvenor AG, Alexander BC, Clark RA, Collins NJ, Ageberg E, Morris HG, Whitehead TS, Crossley KM. (2016) Dynamic single-leg postural control is impaired bilaterally following anterior cruciate ligament reconstruction: implications for re-injury risk. Journal of Orthopaedic & Sports Physical Therapy. 46;357-64.
Culvenor AG, Collins NJ, Guermazi A, Cook JL, Vicenzino B, Whitehead TS, Morris HG, Crossley KM. (2016) Early patellofemoral osteoarthritis features one year after anterior cruciate ligament reconstruction: symptoms and quality of life at three years. Arthritis Care & Research. 68;784-92.
Culvenor AG, Collins NJ, Vicenzino B, Cook JL, Whitehead TS, Morris HG, Crossley KM. (2016) Predictors and effects of patellofemoral pain following hamstring-tendon ACL reconstruction. Journal of Science & Medicine in Sport. 19;518-23.
Culvenor AG, Collins NJ, Guermazi A, Cook JL, Vicenzino B, Khan KM, Beck N, van Leeuwen J, Crossley KM. (2015) Early knee osteoarthritis is evident one year following anterior cruciate ligament reconstruction: a magnetic resonance imaging evaluation. Arthritis & Rheumatology. 67;946-55.